In August 2013 it was announced that she was cast in the lead role in a new Nickelodeon comedy series Instant Mom alongside Michael Boatman and Sheryl Lee Ralph.
In 2015, Mowry starred in the Cooking Channel series Tia Mowry at Home.
Mowry and her sister began entering pageants and talent shows while their family was stationed at Fort Hood, Texas.
After the show ended, both Mowry and her sister studied psychology at Pepperdine University.
From 2006 until 2012, she portrayed medical student Melanie Barnett on The CW/BET comedy-drama series The Game.
She is also notable for starring in the television movie Twitches and its sequel Twitches Too. From September 2013 to 2015, Mowry starred in Nickelodeon's Nick at Nite and TV Land comedy sitcom Instant Mom. Army at the time of her birth, and later became a custody officer/jailer with the City of Glendale Police Department, when the family moved to California.
Tia Mowry and her sister Tamera were in a singing group in the early 1990s called Voices. Her mother, Darlene Renée Mowry (née Flowers), managed her children's careers when they were in the group Voices, and also worked as a security guard. Tamera was born first, at pm, followed by Tia at pm.
The group debuted their first single "Yeah, Yeah, Yeah! She also has two younger brothers, actor Tahj Mowry and Tavior Mowry, who played college football for University of California, Davis.She agreed, on the condition that they land an acting job within the first month of their stay.